Chitrangada Singh began her career in Delhi as a model before making the transition to the silver screen. After completing her education, she entered modeling, where her ad credits include ICICI bank and Alukkas Jewellery, and gradually shifting to music videos, she performed lyricist Gulzar's Sunset Point.
It was in a music video of singer Abhijeet, that was she was spotted by Sudhir Mishra?s production manager. Subsequently, she made her much acclaimed debut with Sudhir Mishra's film Hazaaron Khwaishein Aisi in 2003, the role got her wide acclaim, a Washington Post review noted her for giving "her character a deep sense of dignity and decency.".After that Chitragandha acted in the 2005 film Kal: Yesterday and Tomorrow (2005).
She took a break from acting from 2005 to 2008 In 2008, she made her comeback with the leading role opposite Sanjay Suri in the director Onir's romantic-comedy, Sorry Bhai! (2008). Its release over the weekend of the Mumbai terror attacks proved disastrous at the box office.
She is presently acting for commercial advertisements for Aliva snacks, Taj Mahal tea and Garnier.
She is set to appear in Sudhir Mishra's next movie, Dhruv, where she plays a power-broker.