Meera Vasudevan was born in Mumbai, Maharashtra in a Tamil brahmin family as the eldest daughter to Vasudevan and Hemalatha. After graduating with a Bachelor of Arts degree in Psychology and English literature, she became a successful model, appearing in many ad films, shooting into fame. Her entry into the film industry happened through the 2003 Hindi satirical film Rules: Pyaar Ka Superhit Formula alongside Milind Soman, her Telugu film Golmaal, however, released first. The same year she made her film debut in the Tamil film industry as well, appearing in Samuthirakani's directorial debut Unnai Saranadainthen, in which she shared screen space with Venkat Prabhu and S. P. B. Charan. Her portrayal of Bobby, an adamant village girl, in the film, was appreciated by critics and earned her the Tamil Nadu State Film Special Award for Best Actress.
After unsuccessful films like Anjali I Love You in Telugu and Arivumani in Tamil, she stepped into the Malayalam film industry in 2005 with the Blessy-directed Thanmathra alongside Malayalam superstar Mohanlal. Her performance as Lekha Ramesan, a housewife and mother of two children, received rave reviews and fetched her the Best Female New Face Award at the 2005 Ujala-Asianet Awards.
In 2006, she again starred in a Hindi film, Jaadu Sa Chal Gayaa, after 3 years, following which she appeared in the Tamil comedy film Jerry as a police inspector and the Malayalam drama film Oruvan, in which she again enacted the role of a housewife. Vasudevan next starred in a number of Malayalam-language films, which include Ekantham, Valmeekam and Khaki and two Hindi-language films, Chain Kulii Ki Main Kulii and Thodi Life Thoda Magic in 2007
In 2009, she had three releases so far, the Malayalam-language films Orkkuka Vallappozhum, Decent Parties and Vairam: Fight For Justice, in which she portrayed a Malayali housewife, whose daughter gets molested and killed. Projects she is currently working on include Aattanayagan, co-starring Sakthi Vasu and Remya Nambeeshan and Thasaiyinai Thee Sudinum, a periodic film set in the 1940s.
The ICC setmax campaign was her calling to success and fame and marked her entry into acting. After about 500 failed screentests, the Setmax ad shot by Prahlad Kakkar won the best ad campaign of the year, and was noticed by the director Parvati's mother & got her a screentest for Rules- Pyar ka superhit formula in 2004 for which she was nominated for best upcoming actress by Screen Awards and Sansui - PNC Awards. She is still doing ads in bombay and in the south.She will be seen in more movies shortly.