Sana Saeed who currently resides in Mumbai, India was chosen among two-hundred other children to play Shahrukh Khan & Rani Mukherjee's daughter in Kuch Kuch Hota Hai (1998), her only movie besides Badal (2000) and Har Dil Jo Pyar Karega... (2000) in which she reprised her role from Kuch Kuch Hota Hai (1998) as the little Anjali in a guest appearance. Prior to Kuch Kuch Hota Hai (1998) she had refused Rahul Gupta's Hum Panchi Ek Daal Ke, since she could not continue studying while shooting it; so Kuch Kuch Hota Hai (1998) was shot during her school vacation. She won the Sansui Viewers' Choice Award as the best Child Artist for it.
Her favorite scene in Kuch Kuch Hota Hai is when Shahrukh Khan's character forgets his trousers and she herself thinks her performance during the elocution scene "was not that great."
Currently, she is doing a show on SAB TV that is called Lo Ho Gayi Pooja Iss Ghar Ki.