Jeena Sirf Mere Liye tells the story of two childhood friends Tusshar and Kareena who don't spend a moment without each other. Kareena dreams of a future with her childhood mate, while Tusshar has different plans. Fate intervenes and friends are compelled to part.
Times flies by. Kareena blossoms into a bubbly young girl. Tusshar has turned into a handsome robust youth. Kareena continues to dote on him. But love is too far a thought for Tusshar's preoccupied mind. Efforts to woo him go down the drain.
But Kareena continues to pursue her dream, hoping that one day he will come to her and profess his love for her. Does Kareena's dream stand a chance to turn into reality?