SATYAMEVA JAYATE 2 is the story of a family's fight against corruption. Satya Balram Azaad (John Abraham) is the home minister in a coalition government in Uttar Pradesh. He tries to pass an anti-corruption bill in the assembly but his own alliance partners oppose. Interestingly, one of the MLA who votes against the bill is Satya's wife, Vidya Azaad (Divya Khosla Kumar). She is the daughter of Chandra Prakash (Harsh Chhaya), the Chief Minister of Uttar Pradesh. Meanwhile, the doctors in a government hospital in the state go on strike. A mother pleads them to treat her daughter who has met with an accident. The doctor leading the strike refuses. The victim dies in front of the protesting doctors and media.
The same night, a vigilante (John Abraham), kills the doctor leading the strike in an act of revenge. His death leads to the strike being withdrawn. The vigilante becomes an overnight hero. Chandra Prakash is not impressed and he tells DCP Upadhyaya (Anup Soni) to find the culprit. The DCP hands over the case to Jay Balram Azaad (John Abraham), twin brother of Satya Balram Azaad. On the other hand, another scandal rocks the state as many children fall ill after consuming a meal in a madrasa. In the government hospital where they are admitted, there's shortage of oxygen cylinders.
Hence, 40 of those kids die. Satya finds out that the spoilt foodgrains were supplied by a relative of Tripathi (Daya Shankar Prasad). And the one responsible to supply oxygen in the government hospital is a close aide of Shankar Prasad (Zakir Hussain). Both Tripathi and Shankar are from the alliance party and they threaten to withdraw support when Satya confronts them. It now comes to light that the vigilante is none other than Satya. He now kills both Tripathi and Shankar. A few days later, a third incident occurs as a flyover in the state collapses. The contractor of the flyover, Madan Lal Joshi (Rituraj Singh) refuses to take responsibility. Jay and others conclude that he's going to get killed by the vigilante. What happens next forms the rest of the film.