Jamwal made his acting debut in the 2011 Hindi film Force opposite John Abraham. His performance as the antagonist earned him the Filmfare Award for Best Male Debut. He subsequently played supporting roles in the Telugu films Shakti and Oosaravelli, both starring Jr. NTR.
In 2012, Jamwal made his debut in Tamil cinema with Billa II, as the antagonist opposite Ajith Kumar,The Movie has got him critical applause. He is currently working on another Tamil film Thuppakki, opposite actor Vijay.