ANGREZI MEDIUM is the story of unconditional love between a father and daughter. Champak (Irrfan Khan) is a single parent of Tarika (Radhika Madan) and is based in Udaipur. His brother is Gopi (Deepak Dobriyal) and though both have lot of love for each other, they are also involved in a legal tussle. Both run a shop named Ghasiteram Sweets and both claim to be the original shop running since generations. The matter reaches court where Justice Chheda (Zakir Hussain) gives a verdict in favour of Gopi. In a drunken state, Gopi later reveals that he bribed the judge which is why he won the case. Gajju (Kiku Sharda), a friend of the brothers, records this statement.
Tarika, meanwhile, is an average student and wishes to win the scholarship offered by her school that will take her to London. She works quite hard and manages to get 85% and it makes her eligible for UK scholarship. A felicitation ceremony is held for this occasion. The chief guest here is none other than Justice Chheda. Champak, in anger, informs the crowd of the nefarious activities of Chheda, not realising that Chheda is the husband of the Principal of the school (Meghna Malik).
The Principal, in anger, cancels Tarika's scholarship. Champak promises Tarika that come what may, he'll get her admission done, that too in the college of her choice in London. Sadly, Tarika fails to get the admission from other quotas. Gopi suggests Champak that they contact Bablu (Ranvir Shorey), their childhood friend who is settled in London. Bablu comes to Udaipur on a plane ticket sponsored by Champak. He tells Champak that he can help him get British citizenship after which Tarika can get admission easily.
Champak, Gopi and Tarika reach London airport. Here, Champak and Gopi are mistaken for drug dealers. They are deported back to India while Tarika is stranded in London. What happens next forms the rest of the film.