DE DE PYAAR DE is an unusual love story. Ashish (Ajay Devgn), 50, is based in London. He is separated from his wife, Manju (Tabu). At a common friend's wedding, he comes across Aisha (Rakul Preet Singh) who is 26 years old. She is free-spirited and carefree and both she and Ashish get attracted to each other.
In no time, she moves into his place. When the topic of marriage comes up, Ashish hesitates but realizing how much he loves Aisha, he agrees. He takes her to his hometown in Manali to get his parent's approval. He decides to go there unannounced and as soon as he reaches there, all hell breaks loose.
Ashish has not been in contact with them since years and hence his family comprising of Manju, daughter Ishita (Inayat), son Ishaan (Bhavin Bhanushali), father (Alok Nath) and mother (Madhumalti Kapoor) are startled to see him and that too with Ashish. Ishita gets livid as her to-be-father-in-law Atul (Kumud Mishra) is about to come to meet the family. She is petrified since she told Atul and her boyfriend Rishi (Rajveer Singh) that Ashish is no more! Ashish develops cold feet on seeing so much of negativity upon his arrival. What happens next forms the rest of the film.