Shemaroo Entertainment Ltd., Green Apple Media and Falanshala Media Pvt. Ltd's Mirza Juuliet is essentially a love story between a Hindu girl Juliet (Pia Bajpai) and a Muslim boy Mirza (Darshan Kumar). Juliet lives in Uttar Pradesh with her three brothers Dharmaraj (Priyanshu Chartterjee), Bheem (Hemant Kumar) and Nakul (Yogendra Vikram Singh).
Even though her marriage gets fixed with Rajan (Chandan Roy Sanyal), she hats him because he talks sex all the time on the phone with her. That's when Juliet finds her true love in the form of Mirza, who returns to his hometown after being jailed for a murder that he had committed during his childhood.
After Mirza gets to know about Juliet's marriage with Rajan, he distances himself from her. Around that time, Rajan lands up raping his own wife-to-be Juliet.
What happens next in the lives of all the characters is what forms the rest of the story.