Tiger (Salman Khan) and Zoya (Katrina Kaif) escape from the clutches of ISI and RAW and then they start living an idyllic life somewhere in the snow-covered ranges of Europe. Meanwhile in Ikrit, Iraq, Abu Usman (Sajjad Delafrooz) emerges as the head of ISC which turns into the world's richest and the most dangerous terrorist organization. The Americans are angry and they launch an attack on Abu and his convoy, and it injures Abu.
At the same time, a group of 40 nurses Ã¢â‚¬â€œ 25 Indian and 15 Pakistani Ã¢â‚¬â€œ are heading to the hospital where they work. Abu's men force the nurses to take an injured Abu with them for immediate treatment. They also take over the hospital and keep the nurses as hostage. The Americans then decide to launch an airstrike on the hospital within 7 days. Hence, the Indians have just a week to rescue the nurses. Infiltrating into the high security ISC region is next to impossible.
The senior officer of RAW, Shenoy (Girish Karnad) suggests that Tiger should be called in as he's the only one who can successfully complete this mission. Tiger is found and he takes up the job. How Tiger manages to infiltrate the ISC area and rescue the nurses forms the rest of the film.